OMG..............

https://www.frontiersin.org/articles/10.3389/fimmu.2019.01956/full
vaccine registered in several countries, cannot be administered to non-immune individuals and children younger than 9 years old, due to safety reasons.
Subunit vaccines could be an attractive alternative, because they are usually safe and can be administered in babies younger than 1-year-old but, unfortunately, they are less immunogenic than replicative immunogens.
Subunit vaccine could be safe and attractive antigens for this strategy.
In addition, seronegative travelers from non-dengue endemic countries should not receive this vaccine, because the vaccine could predispose them to more severe dengue if they were exposed to a natural infection.
Unfortunately, despite the good humoral immune response induced in all groups of the study, protection was observed only in animals from the group that received the purified inactivated virus (66); so, the prime-boost immunization strategy did not show an effective response.
When vaccinated animals were challenged with the live virus, all vaccination regimens showed significant protection from viremia, but only animals receiving the combination were completely protected (viremia mean: 0 days) (68).

• Category: Riot/Mayhem/Organized Chaos,TheControllers/TheConspirators,Servants of Evil
• Duration: 10:15
• Date:  2021-06-16 08:37:44
• Tags:   no-tag